Manual cleaning in the pharmaceutical industry. Particularly when it comes to manually cleaning surfaces in contact with the product, the type of cleaner playsValidated automated processes are: • Automated Cleaning and thermal disinfection (EN ISO 15883). • Automated Cleaning and disinfection of flexible Cleaning Validation Manual: A Comprehensive Guide for the Pharmaceutical and Biotechnology Industries - CRC Press Book. 27 Oct 2017 Cleaning Validation Requirements and steps typically practiced Effective manual cleaning practices must be established by focusing on the 19 Sep 2017 Cleaning and Cleaning Validation in the Food Industry. by Kitty Appels . CIP and manual cleaning: what they are and how to validate them.